Cefiderocol—A Different Kind of Cephalosporin
Cefiderocol is a siderophore cephalosporin that features a novel mode of bacterial cell entry and hydrolytic stability against β-lactamases to confer broad activity against aerobic Gram-negative bacteria. Cefiderocol contains an iron-binding catechol moiety that enables the compound to utilize bacterial iron uptake transporters to gain cell entry and access penicillin-binding proteins. This mechanism of action and unique mechanism of cell entry require adaptations to standard susceptibility testing
Learn how cefiderocol works against Gram-negative bacteria by viewing an MOA/MOCE animation, watching the “Understanding Cefiderocol” video, and exploring cefiderocol’s spectrum of activity.
Review cefiderocol susceptibility trends by exploring cefiderocol’s spectrum of activity, examining data from the SENTRY Antimicrobial Surveillance Program, and assessing other surveillance data for deeper insights.
Access resources to help you perform cefiderocol susceptibility testing via disk diffusion, broth microdilution, or through a reference laboratory.
Get the tools you need for in-house cefiderocol testing and quality assurance, including verification / validation isolates, reading methods and MIC results, and general antimicrobial susceptibility testing guidance.
Learn more about potential mechanisms of resistance to cefiderocol and send resistant isolates to Shionogi’s testing program for analysis.
Abbreviations: MIC=minimum inhibitory concentration; MOA=mechanism of action; MOCE=mechanism of cell entry.